SWIDDICH is a national ongoing study with multiple sites across Sweden seeking to answer the question “Can iodine substitution improve children’s development?” To be able to do this, every participating family is important as we need to recruit 1275 pregnant women. All participants are randomised into two groups where both will be given a multivitamin tablet, but in one group the tablet also contains 150 µg iodine and in the other control group, the vitamin tablet is without iodine.
Our goal is to have healthy and prosperous children and we know that iodine is important for the function of the thyroid gland. Iodine is found in dairy products, fish and seafood, and iodine enriched table salt. Studies have shown that there is no dangerous iodine insufficiency in Sweden today even if iodine intake has decreased in the population during the last few decades. The SWIDDICH study will investigate what importance an iodine substitution during pregnancy has for the children’s health. We will therefore follow the children’s health during their development.
Initially you, in early pregnancy, will be prescribed a vitamin tablet with or without iodine to be taken daily until delivery. During the pregnancy, iodine levels will be measured on three occasions. After delivery, we will follow the children with a strong focus on cognitive development. Iodine is important for the brain’s development during fetal life which is why the children will be examined by a psychologist who will evaluate the children’s cognitive ability. The parents will fill in a questionnaire about their child’s behaviour. We are also interested in the children’s iodine levels, thyroid hormones, and related factors. We will also collect information regarding circumstances that can influence the iodine levels with the help of a questionnaire.
Supplementary information regarding the parents/caregivers and the child’s health and living conditions will be collected. Information about the children and the pregnancy will be collected via medical records of hospitals, primary care centres, maternity care centres, child care centres, school health care, and from National Quality Registers (Pregnancy Record Register, Swedish National Neonatal, Child Care and School Care Quality Register), National Board of Health and Welfare (The National Patient Register, The Swedish Prescribed Drugs Register, The Swedish Birth Register) and Statistics Sweden (population registration and facts including education and study results). All collections are approved by the Swedish Ethical Review Authority and no participators will be personally identified in published research results.
If you have heredity thyroid gland diseases, earlier history of thyroid gland disease, have other autoimmune diseases or symptoms of thyroid gland disease, the blood test performed at the Maternity Care Centre must be normal.
Since the study means that you can be prescribed a dietary supplement containing iodine, you must refrain from taking other multiple vitamins until delivery. You can take supplements of folic acid and iron beyond the prescribed dietary supplement.
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